We Excel in Supporting Precision Medicine Development
Funding from the National Institutes of Health enabled InvivoSciences to demonstrate reconstitution of various patient-specific disease phenotypes in micro-engineered heart tissues; now we call them “NuHeart™“. In collaboration with a cardiologist, Dr. Jennifer Strande, at the Medical College of Wisconsin, we are mass-producing NuHearts™ using iPSCs obtained from patients’ cells or gene-edited iPSCs carrying only a disease-causing single mutation.
InvivoSciences Cares about Rare Disease Drug Discovery
- There are ~7,000 rare diseases, but >30 million people are affected when combined
- Half of them are children
- So many of them affect heart muscle and skeletal muscle, and some affect connective tissues, for which we can potentially develop micro tissue disease models in a dish
The 3D tissue strip culture is our patented unique 3D culture technology different from 3D spheres or 3D printed tissues. It is an optimized approach to reconstitute muscle (skeletal, cardiac, smooth) and connective tissues including dermis of the skin in micro-well plates. Based on the invention, we fabricate NuHeartTM and conditioned (e.g., mechanical stretching) to mature for analyzing their electrophysiology, contractility, and profibrotic phenotypes using our high-throughput and high-content phenotypic compound screening platform; we call it, Live-in-Tissue Analyzer (LITATM).
To improve the assay efficiency and reproducibility, processes of cell derivation (e.g., iPSC culture and differentiation) can be optimized for each iPSC line by screening culture conditions.
These award-winning technologies help de-risk the therapeutic development efficiently and quickly. InvivoSciences has won numerous awards since its launching in 2001. A full list of awards can be seen here.